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  • 08월 28일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Combinatorial Discovery of Full-color-tunable Emissive Fluorescent Probes Using a Single Core Skeleton, 1,2-Dihydropyrrolo[3,4-b]indolizin-3-one

등록일
2008년 8월 11일 22시 45분 58초
접수번호
0932
발표코드
금34A1구 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 09시 : 10분
발표형식
구두발표
발표분야
유기화학
저자 및
공동저자
김은하, 고민섭1, 박승범
서울대학교 화학부, Korea
1서울대학교 화학과, Korea

We developed a novel fluorescent core skeleton, 1,2-dihydropyrrolo[3,4-β]indolizin-3-one, by complexity-generating one-pot reactions through 1,3-dipolar cyclization followed by oxidative aromatization. This fluorescent core skeleton can accommodate various wavelengths of emission maxima by changing the electronic properties of substituents, which was postulated by computational studies. The full-color-tunable emission maxima were achieved with a single core skeleton by changing the substituents using the combinatorial approach. These novel fluorophores have excellent photophysical and photochemical properties: moderate to excellent quantum yields, resistance to the photobleaching, pH-independent fluorescence, large Stokes shifts, drug-like lipophilicity for membrane permeability, etc. Further, we successfully demonstrated the bioapplication of fluorophores B1 & B5 in the immunofluorescence for visualizing cellular compartments of HeLa cells.


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