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  • 08월 28일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Stereoselective Synthesis of Chiral Building Blocks of Epoxyquinol A and B By Using Enantioselective Diels-Alder Reaction

등록일
2008년 8월 12일 11시 24분 28초
접수번호
1221
발표코드
34P279포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 <발표Ⅲ>
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
채희일, JINMINGYU1, 류도현
성균관대학교 화학과, Korea
1성균관대학교 화학과, China

Cyclohexene epoxide compounds, frequently found in natural products, exhibited wide range of interesting biological active properties. One of these natural products, epoxyquinol A and B show potent antiangiogenesis activity. Angiogenesis is a physiological process involving the growth of new blood vessels from pre-existing vessels. This process is required for invasive tumor growth and metastasis in the control of cancer progression. Thus, its inhibition can be a valuable new approach to cancer therapy. Epoxyquinol A and B are generated from the epoxyquinol monomer (1) by oxydation and subsequent 6π-electrocyclization.The enantioselective synthesis of chiral monomer (1) of epoxyquinol A and B was achieved through a catalytic enantioselelctive Diels-Alder reaction of iodoquinonemonoketal and cyclopentadiene. We expect that this new synthetic route can be useful for the synthesis of various cyclohexene epoxide natural products.


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