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Synthesis of "Reversed" Diamidino 3,6-Diarylcarbazoles based dicationic molecules as Antimicrobial Agents

등록일
2008년 8월 12일 11시 26분 46초
접수번호
1229
발표코드
34P280포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 <발표Ⅲ>
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
이호창, Chennan Ramalingan1, 곽영우
경북대학교 화학과, Korea
1경북대학교 화학과, India
Dicationic molecules are one of the important classes of antimicrobial agents. Analogs of this type have typically utilized amidine functionalities as the cationic moieties and their activities against various pathogenic strains have been reported. A variety of compounds in this class of dicationic molecules has been shown to bind to the minor-groove of DNA at AT-rich sites. Various diphenylfuran diamidines have been found to be highly effective treatments in animal models for Pneumocystis carinii and Cryptosporidium parvum. On the other hand, chemical entities possessing carbazole scaffold have been associated with various biological properties. Having the significance of diamidine class of compounds and molecules possessing carbazole scaffold in the field of medicinal chemistry in mind, a series of novel dicationic chemical entities possessing diarylcarbazoles and amidines or guanidines as dicationic moieties have been synthesized from readily available carbazole via a multi-step synthetic strategy involving Suzuki cross coupling reaction as a key step. The structure of all the synthesized target dicationic molecules was established based on their physical and spectral properties. Microbiological evaluation of all the dicationic molecules will be studied in due course.

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