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  • 08월 28일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

PLGA Nanoparticles and Nanohalf-shells contaning sulphorhodamine B as hydrophilic model drug: Preparation, characterization and In vitro studies

등록일
2008년 8월 12일 11시 28분 54초
접수번호
1238
발표코드
28P27포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅱ>
발표형식
포스터
발표분야
고분자화학
저자 및
공동저자
김성철, 강수용, 박아름1, Odonchimeg2, 심영기1, 이우경1
인제대학교 나노시스템공학과, Korea
1인제대학교 나노공학부, Korea
2인제대학교 나노공학과, Mongolia
Poly(lactide-co-glycolide) (PLGA) nanoparticles and nanohalf-shells containing sulphorhodamine B as hydrophilic model drug were prepared by W/O/W emulsion solvent evaporation method. Half-shell structures were prepared by adding poloxamer (F-127) to the organic phase containing PLGA 504H. PLGA nanoparticles and nanohalf-shells were prepared by using various factors. The field emission scanning electron microscope (FE-SEM) and particle size ananlyzer (PSA) were used to study the morphology and particle size of the nanoparticle and nanohalf-shell, respectively. HPLC was performed to determine the encapsulation efficiency(EE%). The mean size and encapsulation efficiency(EE%) were influenced by the amount of poloxamer added. The drug release behavior was also influenced by the structure of particles.

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