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  • 08월 28일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Solid-Phase Synthesis of pyrazolo[1,5-a][1,3,5]triazine Derivatives via Dithiocarbazate Linker

등록일
2008년 8월 12일 11시 30분 37초
접수번호
1247
발표코드
35P330포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅰ>
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
류인애, 유은애1, 하덕찬, 공영대1
고려대학교 화학과, Korea
1한국화학연구원 신약기반기술연구센터, Korea
Solid-Phase synthesis of combinatorial libraries has emerged as a powerful tool for efficient drug discovery process. As a part of our high-throughput synthesis program for drug discovery, we are trying to explore the potential of resin-bound dithiocarbazate as a versatile intermediates for generation of drug-like pyrazolo[1,5-a][1,3,5]triazine derivatives. Herein, we would like to present novel solid-phase synthetic method for construction of a pyrazolo[1,5-a][1,3,5]triazine from cyclization of urea synthesized by reaction with isocyanates, isothiocyanates from our previously reported resin-bound 5-amino-1-(substituted thiocarbamoyl)pyrazole derivatives. The progress of reactions could be monitored as solid-bound intermediates by ATR-FTIR spectroscopy. The final compounds were obtained in good yields and high purities.

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