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Structural Investigation of Nanocrystalline Hydroxyapatite with Different Aging Time

2008년 8월 12일 12시 37분 38초
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금 17시 : 10분
저자 및
송영규, Christian Rey1, 조경구
한국기초과학지원연구원 자기공명연구부, Korea
1Institut National Polytechnique de Toulouse, Toulouse, France, France
Although it is widely known that bone mineral crystals are compositionally and structurally similar to synthetic calcium hydroxyapatite, Ca10(OH)2(PO4)6 (HAP), biological properties of them are different from those of the synthetic HAP. For example, it is well established that pure, stoichiometric hydroxyapatite remodels slowly in tissue: a stoichiometric implant is largely bioinert. However, an "imperfect" apatite is a better "chemical match" with the crystals of host bone, and is readily remodeled by the BMU (basic multicellular unit). It is necessary to synthesize HAP having biological properties similar to the bone mineral to use it as bone implant materials. Thus, we synthesized nanocrystalline HAP containing HPO42- which was aged to 22 days and have studied the structure of the nanocrystal HAP using solid state NMR and XRD. Ca/P ratio was measured using ICP-MAS. As the aging time increases, the ratio increases. XRD was used to measure crystallite sizes. The crystallite sizes increase with the increase with the aging time. The range of the crystallite size is about 150 to 340 Å. 1H magic angle spinning (MAS) NMR is used to identify chemical composition and to measure the content of individual components. Three peaks arising from hydroxyl ion, surface-adsorbed water, and acid phosphate (HPO42-) are observed. The contents of the individual components was measured using deconvolution and were normalized to the contents of the sample with 0 hour aging time. The content of the hydroxyl ion increases as the aging time increased. The water content increased to 5 hour aging time and then decreased with the increase the aging time. The content of acid phosphate decreased until 1 day aging time and then increased after that. 2D HetCor 1H-31P NMR techniques was to used 1H and 31P connectivity to help peak assignment.