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Novel Octahydro Indeno Derivatives as Potential Antitumor Agents

등록일
2008년 8월 12일 12시 38분 46초
접수번호
1410
발표코드
34P317포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 <발표Ⅲ>
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
양유선, JIANG SHUAI1, 류도현2
(주)푸드사이언스, Korea
1성균관대학교 화학과, China
2성균관대학교 화학과, Korea
Ottelione A,isolated from the freshwater plant Ottelia alismoides, was found to show prominent biological properties such as antitubercular and antitumor activities. Screening against a panel of 60 human cancer cell lines at the National Cancer Institute in the United States revealed the cytotoxocity of Ottelione A at the nM-pM levels. Biological studies by a research group at Aventis reported that Ottelione A is an efficient inhibitor of tubulin polymerization (IC50=1.2M) and can disassemble preformed microtubules to represent a new class of inhibitor of microtubule assembly with potential therapeutic value. As a program for developing new antitumor agent based on the structure of Ottelione A, we prepared new octahydro indeno derivatives. Among them, tricyclic indenoderivatives showed very high cytotoxicity against tumor cells to serve as a candidate of new antitumor drug.

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