Baylis-Hillman type adducts were found to directly inhibit the growth of tumor cells. Particularly, β- branched Morita- Baylis- Hillman (MBH) esters are useful precursors for the synthesis of various biologically active molecules and natural products. However, these esters are not easily accessible by the general MBH reaction. Although, some methods were reported recently for the synthesis of these MBH type adducts but their asymmetric conversions has been limited.
Herein, we wish to report oxazaborolidinium ion catalyzed tandem three- component coupling reaction for the synthesis of enantioselective β- iodo MBH esters with excellent Z/E selectivity and ee.