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  • 08월 28일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Rationally Designed Fluorescence ‘Off-On’ Cu2+ Sensor and α-amino-carboxylates Sensor

등록일
2008년 8월 21일 11시 00분 57초
접수번호
1570
발표코드
31P171포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅱ>
발표형식
포스터
발표분야
물리화학
저자 및
공동저자
고경철, 강선우, 이진용
성균관대학교 화학과, Korea
A new coumarin-based fluorescent sensor has been synthesized by a rationally designed fluorophore, imino-coumarin (IC), in 85% yield. It displays a high selectivity for Cu2+ over the various metal cations and a significant fluorescence enhancement of IC takes place in the presence of Cu2+ in aqueous solution by geometry isomerization block (FEGIB) mechanism. The ab initio calculations proved that the fluorescence ‘Turn-On’ of IC originates from the fact that C=N isomerization of IC is blocked upon complexation with Cu2+, hence the non-radiative decay caused by the C=N isomerization does not occur in the excited state. Anthracene-based bis(trifluoroacetylcarboxanilide) sensor is structurally simple but selectively senses α-amino acids as their carboxylate forms over β- and γ-homologues by forming a cyclic adduct. The approach primarily relies on the perturbation of the quenching n-π* transition energy level of the carbonyl ionophore relative to the π-π* transition energy level of the flurophore in the sensor. Calculated frontier molecular orbitals(MOs) of sensor and its glycinate adduct show the reason of fluorescence enhancement.

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