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  • 08월 28일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

2-D Nanoparticles Intercalated with Anticacer Drugs for Target Delivery

2008년 8월 29일 17시 39분 06초
목20B3심 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 15시 : 20분
재료화학 - Multi-Functional Hybrid Materials I
저자 및
지능형나노-바이오소재연구센터 화학 나노과학과, 이화여자대학교, Korea
Biomolecular-inorganic nanohybrids with two different functions, one from inorganic moiety and the other from biological or organic one, have been realized for drug delivery system. Recently we have developed a new hybrid systems consisting of anticancer drugs like methotrexate (MTX) or 5-Fluorouracil (5-FU) and two-dimensional inorganic compound like layered double hydroxide (LDH) as a drug delivery carrier. To the best of our knowledge, such an inorganic vector is completely different from conventionally developed ones such as viral-based, naked DNA, cationic liposomes and biodegradable polymers, those which are limited in certain cases of applications due to their toxicity, immunogenecity, poor integration, and etc. But the above mentioned problems can be overcome by synthesizing inorganic nanovehicles properly with non-toxic metal ions having biological compatibility. Moreover, we found that LDH could protect chemically fragile anticancer drugs very efficiently under harsh experimental conditions. In addition, we have clearly demonstrated that the intercellular mechanism and pathways of LDH nanoparticles are principally related to clathrin mediated endocytosis. As the typical examples of inorganic drug delivery system, MTX-LDH and 5-FU-LDH nanohybrids will be demonstrated not only in-vivo but also in vitro.