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  • 08월 28일 16시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Cancer Biomarker Discovery from Human Plasma Proteome by Mass Spectrometry

등록일
2008년 9월 1일 10시 58분 34초
접수번호
1619
발표코드
금15J2심 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 14시 : 40분
발표형식
심포지엄
발표분야
생명화학 - Omics & Personalized Medicine II
저자 및
공동저자
유종신
한국기초과학지원연구원, Korea
Due to the high complexity of human plasma, it is normally hard to detect secreted proteins to discover the useful cancer biomarkers for personalized medicine. To discover candidate disease markers in the human plasma, therefore, is challenging in proteomics. We used pooled plasma sample of normal and cancer patients to statistically profile peptide patterns from the plasma proteins by mass spectrometry (MS). From the peptide pattern profiling with quantitative MS analysis, we discovered the group of peptides from glycoproteins, each of which showed quite different quantity from other peptides belonging to the same glycoproteins. For validating the targeted peptides from different plasma samples, multiple reaction monitoring from linear ion trap with Fourier Transform MS was tried and also run by principal component analysis. From this method, we clearly classified the candidate peptides from normal and cancer group for cancer biomarker discovery.

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