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  • 01월 01일 09시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Searching for New Reactivity via Transition Metal Catalysis

등록일
2005년 3월 8일 10시 52분 50초
접수번호
1106
발표코드
금11A1분념 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 14시 : 10분
발표형식
분과기념
발표분야
유기화학 - 유기화학의 새로운 흐름
저자 및
공동저자
장석복
한국과학기술원 화학과,
Transitionmetal-catalyzed organic transformations have been developed to the level of mature area in some aspects although there are plenty of rooms to improve. We have searched for new catalytic utility using transition metals such as Ru, Rh, Pd, and Cu. Among those, we have recently developed, on the basis of a chelation-strategy, an efficient copper-catalyzed aziridination protocol with the use of 5-methyl-2-pyridinesulfonamide as a nitrogen source and readily available oxidant PhI(OAc)2. The reaction proceeds smoothly under mild conditions to give aziridines in moderate to good yields in the absence of external ligands or bases. We have also discovered a highly efficient, mild, and practical multi-component reaction for the synthesis of amidines, which are prominent structural motifs in numerous bio-active natural products, important pharmacophores, synthetic intermediates, and efficient coordinating ligands. This reaction has an extremely wide scope with regard to all three coupling components of alkyne, sulfonylazide, and amine.

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