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  • 02월 23일 15시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Nitric oxide-releasing silica nanoparticles and their applications for improving the biocompatibility of in vivo glucose biosensors

2009년 2월 14일 17시 47분 19초
금19F3심 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 11시 : 30분
전기화학 - Young Electrochemist Symposium II
저자 및
광운대학교 화학과, Korea
Designing in vivo biosensors for real-time monitoring of glucose remains a significant challenge due to poor biocompatibility resulting from the inflammatory response, bacterial infection, and fibrous capsule formation around the sensor. Several strategies have been explored to improve the biocompatibility of such devices including the use of silicone rubber, polyurethane, hydrogels, and Nafion, for example. Antimicrobial agents including antibiotics and polyclonal antibodies have also been doped into polymers such that their slow leaching with time decreases bacterial adhesion and biofilm formation at the material-tissue interface. Unfortunately, none of the above strategies has dramatically improved the long-term performance of in vivo glucose sensors. Infection and scar tissue formation still dictate sensor durability. Nitric oxide (NO) plays a key role in numerous physiological processes including immune response and wound healing. In previous work, we synthesized NO-releasing sensor coatings via amine-functionalized xerogel films and discovered an unexpected reduction in analyte permeability and sensor response. Herein, we describe the use of NO-releasing silica nanoparticles doped into polyurethane to fabricate NO-releasing glucose sensor membranes. In addition to biosensor fabrication, the properties of silica nanoparticles as NO storage/release vehicles and the attributes of the NO-releasing polyurethane as biocompatible membranes are presented.