The synthesis of a series of Catechin-conjugated chlorins is done by modification of 3-vinyl group or 17-methyl ester group of chlorophyll-a derivatives such as methyl pyropheophorbide-a (Mppa) and purpurinimide. The structures of new chlorophyll derivatives were characterized by UV, IR, 1H NMR spectra and elemental analysis. New derivatives will show potent photodynamic activities via Type III mechanism which is characterized having radical scavenger.
chlorin, catechin, chlorophyll-a
derivative, photodynamic therapy (PDT)