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  • 02월 23일 15시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Diagnosing Protein misfolding diseases.

등록일
2009년 3월 5일 14시 12분 20초
접수번호
1568
발표코드
목11H5심 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 16시 : 10분
발표형식
심포지엄
발표분야
생명화학 - Protein-Folding & Disease
저자 및
공동저자
Seong Soo A. An
Dept. of Bionano Technology, Kyungwon University, Korea
The term, “Protein misfolding diseases (PMD)” is recent terminology and a very comprehensive term in the post-genome era. With growing generations of elderly patients with PMD, especially Alzheimer's Diseases (AD), and with recent crisis with Bovine Spongiform Encephalopathy, many researchers realized that PMD has not been investigated in depth nor learn from other PMD. The limited analytical tools and clear diagnoses also hampered the development of the therapeutics against PMD. Many cutting edge advances to stop the spread of Transmissible Spongiform Encephalopathy (TSE) or Prion disease, were developed, which in turn could help to investigate AD or other PMD, like Parkinson's Disease, Huntington's Disease, Amyotrophic Lateral Sclerosis, etc. Most causes of PMD, including AD and TSE, were due to the aggregated forms of the misfolded peptides and proteins, where some forms could become neurotoxic and/or infectious in the process. Neverthless, the aggregated form of misfolded proteins could be the biomarker, a target of diagnosis and therapeutic development. Hence, what would be the better methods to differentiate the aggregated forms from the normal in each PMD. Various methods from TSE will be discussed.

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