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  • 09월 04일 13시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Synthetic Lipid Bilayer Platform for Bioanalytical Applications

2009년 8월 12일 14시 12분 41초
금13E4심 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 10시 : 30분
분석화학 - Development and Applications of Analytical Chemistry in Bio- and Nano-Technologies
저자 및
서울대학교 화학부, Korea
The development of sophisticated diagnostic technologies to tailor appropriate combinations of therapeutic methods to individual patients is of paramount importance for the early treatment and eradication of numerous devastating and infectious diseases. Current techniques for genetic screening and protein expression profiling, while fortuitously successful in some cases, are indirect and cannot be expected to comprehensively cover the disease space. In many cases, however, early, fast, and accurate diagnosis is not possible with current methods. The overall objective of our research effort is the development of new, hybrid technologies that use a model cell membrane platform, supported lipid bilayer (SLB), to detect molecular interactions between cell membrane and molecules of interest and to interface live cells with non-living materials that are useful for biological and medical applications. This work involves deciphering the molecular language by which cells communicate, developing new methodologies for the manipulation and control of biological molecules, and the integration of these developments into functional systems. The core scientific strategy is based on reassembly of lipids and proteins into membrane structures supported on inorganic scaffolds. These so-called supported membranes recapitulate many of the properties of live cell membranes that diffuse freely and engage their cognate receptors on the cell in a life-like manner. Here, we propose supported membrane-based methods that provide a uniquely powerful solution to the growing demand for molecular and cellular diagnostic tools. Applications include electrophoretic detection of membrane-binding targets using fluid lipids and optical imaging of lipid-tethered gold nanoparticle for the detection of membrane receptor-ligand interactions.