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  • 09월 04일 13시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Molecular design of novel stimuli-responsive polymers and gels based on amphiphilic functional polyaspartamides for drug delivery

등록일
2009년 8월 12일 19시 26분 04초
접수번호
0439
발표코드
목24I3구 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 17시 : 30분
발표형식
구두발표
발표분야
고분자화학 - General Topics on Polymer Science I (대학원생 발표)
저자 및
공동저자
문종록, 김지흥
성균관대학교 화학공학과, Korea
Recently, the interest in stimuli-responsive materials has increased during the last decades. Among them, polymer systems that undergo nano-aggregations (or micelle formation) and hydrogel in response to biological temperature and pH have been widely investigated for tissue engineering, gene and tumor targeting delivery. Here, we report recent work on the characterization and application of smart biomaterial based on the polyaspartamide(PASAM)-based biodegradable copolymers. A series of amphiphilic polyaspartamide derivatives with the combination of different amines including N-isopropylethylenediamine (NIPEDA), 2-diisopropylaminoethylamine (DIPAEA), ethanolamine (EA), O-(2-aminoethyl)-O`-methylpolyethylene glycol (MPEG), alkylamines (hexyl HA, octyl OA, and lauryl LA), were synthesized from polysuccinimide (PSI) via successive nucleophilic ring-opening reaction. The composition of the prepared amphiphilic copolymers was analyzed by H-NMR. Molecular design of novel copolymers and hydrogels (chemical or physical) based on amphiphilic polyaspartamide derivatives containing cationic pendants were investigated to identify materials as double-responsive (temperature and pH) polymers and gels potentially useful for biomedical applications including controlled and targeted drug delivery system.

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