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  • 09월 04일 13시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

pH-Dependent Structures of an i-Motif DNA in Solution

등록일
2009년 8월 13일 08시 54분 03초
접수번호
0456
발표코드
목24I4구 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 17시 : 40분
발표형식
구두발표
발표분야
고분자화학 - General Topics on Polymer Science I (대학원생 발표)
저자 및
공동저자
노예철, 안병철, 진상우, 이택준, 박삼대, 김진철, 김동민, 정정운, 권원상, 김미희, 고용기, 이문호
포항공과대학교 화학과, Korea
We have investigated for the first time the structure of i-motif DNA in solution at various pH conditions by using synchrotron small-angle X-ray scattering technique. To facilitate direct structural comparison between solution structures of i-motif DNA at various pH values, we created atomic coordinates of i-motif DNA from a fully folded to unfolded atomic model. Under mild acidic conditions, the conformations for i-motif DNA appeared to be similar to that of the partially unfolded i-motif atomic model in overall shape, rather than the fully folded i-motif atomic model. Collectively, our observations indicate that i-motif DNA molecule is structurally dynamic over a wide pH range, adopting multiple conformations ranging from the folded i-motif structure to a random coil conformation. As the i-motif structure has been used as an important component in nanomachines, we can therefore believe that the structural evidence presented herein will promote the development of future DNA-based molecular-actuator devices.

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