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  • 09월 04일 13시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Substituted Flavone; A Novel Antiviral Scaffold

2009년 8월 13일 10시 58분 16초
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목 16시 : 50분
의약화학 - Current Struggles against Infectious Diseases
저자 및
건국대학교 생명공학과, Korea
With 170 million people infected worldwide and lack of the specific antiviral treatment option, hepatitis C virus (HCV) infection represents a major global health threat. In addition, because of the error-prone nature of HCV RNA replication, drug-resistance mutants will develop that is associated with reduction in the effectiveness of the antiviral drugs. Thus, current active pursuit of the specific antiviral agents against HCV has to be concerned about the possible drug resistance issue against the antiviral agent under development. In general, combination therapy for treatment of drug resistant virus combines three or more drugs from at least two different classes to suppress the viral replication in at least two different ways. Combination therapy, however, remains an expensive option and increases life-threatening toxicities. In this study, in order for more efficient and safe combat against the drug-resistant virus, we attempted to design a dual enzyme inhibitor which inhibits two key viral enzymes at the same time. In this context, we envisaged that a natural nucleic acid mimic flavone scaffold might competitively bind at the substrate binding sites of both HCV polymerase and helicase which use nucleic acids as the common substrate. Design, synthesis, and antiviral activity of novel flavone analogues against HCV polymerase as well as helicase will be presented.