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초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

현재 가능한 작업은 아래와 같습니다.
  • 09월 04일 13시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Tumor Homing Nanoparticles for Cancer Imaging and Therapy

등록일
2009년 8월 13일 13시 13분 35초
접수번호
0488
발표코드
금15H4심 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 11시 : 00분
발표형식
심포지엄
발표분야
생명화학 - Nanomaterials and Nucleic Acids for Molecular Therapy
저자 및
공동저자
김광명
한국과학기술연구원 의과학연구센터 , Korea

This presentation proposes a new polymeric nanoparticle-based technology that offers unprecedented paradigm shift opportunity to cancer theragnosis (therapy and diagnosis). Interdisciplinary research in the interface of polymer chemistry and the biomedical sciences has produced various nano-sized drug carriers and imaging probes for both therapy and diagnosis. With the help of polymer chemistry, we propose novel polymeric nanoparticles for the development of smart probes and new drug carriers for the treatment and imaging various cancers. For example, chitosan-based nanoparticles were labeled or loaded of various imaging agents and therapeutic drugs which demonstrated specific cancer imaging and therapy. Nanoparticles based cancer theragnosis holds great promise for a myriad of cancer treatment. Fig. (a) Time-dependent biodistribution of Cy5.5 labeled HGC nanoparticles in tumor-bearing mice. (b) Fluorescence images of Cy5.5 labeled HGC nanoparticles treated cells showing cellular uptake. (c) in vivo anti-tumor activity of PTX loaded HGC nanoparticles. The symbols are as follows: saline (●), HGC (■), cremophore EL-based PTX (▲), PTX-HGC 20 mg/kg (▼), and PTX-HGC 50 mg/kg (◆).


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