This presentation proposes a new polymeric nanoparticle-based technology that offers unprecedented paradigm shift opportunity to cancer theragnosis (therapy and diagnosis). Interdisciplinary research in the interface of polymer chemistry and the biomedical sciences has produced various nano-sized drug carriers and imaging probes for both therapy and diagnosis. With the help of polymer chemistry, we propose novel polymeric nanoparticles for the development of smart probes and new drug carriers for the treatment and imaging various cancers. For example, chitosan-based nanoparticles were labeled or loaded of various imaging agents and therapeutic drugs which demonstrated specific cancer imaging and therapy. Nanoparticles based cancer theragnosis holds great promise for a myriad of cancer treatment.
Fig. (a) Time-dependent biodistribution of Cy5.5 labeled HGC nanoparticles in tumor-bearing mice. (b) Fluorescence images of Cy5.5 labeled HGC nanoparticles treated cells showing cellular uptake. (c) in vivo anti-tumor activity of PTX loaded HGC nanoparticles. The symbols are as follows: saline (●), HGC (■), cremophore EL-based PTX (▲), PTX-HGC 20 mg/kg (▼), and PTX-HGC 50 mg/kg (◆).