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  • 09월 04일 13시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Nafion films : Excellent Candidate for Biomaterial.

2009년 8월 13일 13시 32분 25초
금24I1구 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 17시 : 20분
고분자화학 - General Topics on Polymer Science I (대학원생 발표)
저자 및
김진철, 김가희, 이택준, 박삼대, 진상우, 김동민, 정정운, 노예철, 안병철, 권원상, 김경태, 김미희, 고용기, 이문호
포항공과대학교 화학과, Korea
We investigated bioadhesion (bacterial and cell adhesion) and biocompatibility of Nafion and compared the results with those of poly(vinylidene fluoride-co-hexafluoropropylene) (PVFHFP). When incubated with bacteria for 4 h to 7 days, Nafion film exhibited scarce bacterial adhesion at 6 h, after which the adhesion was gradually increasing to relatively low levels. In contrast, significant bacterial adhesion to PVFHFP film was observed at 4 h, and much higher adhesion levels were shown after then. Although HEp-2 human cells adhered normally to both films reaching confluence in 7 – 8 days, the cells adhered to Nafion appeared more lively and stable than those to PVFHFP. Subcutaneous implantation in mice revealed that Nafion elicited a mild acute inflammatory reaction without chronic inflammation or tissue necrosis, indicating excellent biocompatibility in mice. PVFHFP, however, provoked a moderate and prolonged acute inflammatory response. These differences in the biological characteristics of Nafion and PVFHFP films may be attributable to the differences in the chemical and physical natures of these polymer films. Nafion film provided a sufficiently solid support, expressing a high surface charge density and good water-wettability. In summary, Nafion is suitable for use in biomedical applications that require biocompatibility with a reduced possibility of post-operative infections.