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  • 09월 04일 13시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Shell-crosslinked Magnetic Nanoparticles for Targeted Labeling and Imaging

등록일
2009년 8월 13일 14시 09분 03초
접수번호
0497
발표코드
금15H1심 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 09시 : 10분
발표형식
심포지엄
발표분야
생명화학 - Nanomaterials and Nucleic Acids for Molecular Therapy
저자 및
공동저자
이해신
한국과학기술원 화학과, Korea
We prepared highly stable and functionalized magnetic nanoparticles for targeted labeling and imaging applications. A library of functionalized PEGs was screened to transfer and stabilize organic synthesized iron oxide nanoparticles (IONPs) in aqueous solution by a vacuum-drying method. For preparing highly stable nanoparticles and their specific targeting, the coated PEG on IONPs were crosslinked using hyaluronic acid. The shell-crosslinked magnetic nanoparticles exhibited high stability in aqueous solutions with various pH and high salt concentrations for over a month, compared to IONPs coated only with 6PEG-NH2. The shell-crosslinked magnetic nanoparticles also showed enhanced internalization into cells expressing CD44 receptor, such as mesenchymal stem cells, by specific uptake. The shell-crosslinked magnetic nanoparticles showed high application potentials for stem cells and trafficking, or targeted cancer imaging.

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