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  • 09월 04일 13시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Recent Trends in the Development of New Antibiotics against Superbugs

2009년 8월 13일 20시 19분 30초
목18F2심 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 14시 : 05분
의약화학 - Current Struggles against Infectious Diseases
저자 및
한동대학교 생명과학부, Korea
Recently, the use of antibiotics has been hampered by the continuous emergence of resistant bacteria. Therefore, the constant development of new antibiotics is necessary to overcome the emerging resistance. The new families of antibiotics were discovered traditionally by random screening of natural products and chemical libraries. For the last 3 decades most research has been dedicated to the improvement of existing classes of molecules rather than on the development new families of antibacterial agents. However, the recent aim of the pharmaceutical industries is obviously to be one step ahead rather than behind bacteria in this continuous race by developing new antibiotics acting on new targets against which no specific resistance preexists. Choosing new targets for which no natural product inhibitors are known markedly decrease the emergence of specific resistance mechanisms. Rationally selected bacterial targets should lead to more powerful new agents with well defined behavior. New technologies such as bacterial genomics are becoming available for more efficient target selection. Some pharmaceutical companies seek to identify bacterial genomes that are essential to bacterial viability in vitro or to bacterial growth and virulence in vivo. Inhibition of virulence factors rather than bacterial death could provide an alternative and more ecological therapy. In this presentation, new targets for new antibiotics, which are under development by several pharmaceutical venture capitals, will be discussed