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Dynamics of the HIV-1 Nucleocapsid Protein : A Molecular Dynamics Study

등록일
2009년 8월 14일 09시 30분 11초
접수번호
0718
발표코드
34P92포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅰ>
발표형식
포스터
발표분야
물리화학
저자 및
공동저자
홍주연, 함시현
숙명여자대학교 화학과, Korea
The HIV-1 nucleocapsid protein (NCp7) is a highly conserved protein generated by processing of the Gag polyproteins during retrovirus maturation. It has been widely studied that NCp7 protein was regarded as a potential target for the development of antiviral drugs. The two CCHC-type zinc knuckle domains of the NCp7 were known as the critical parts for the NCp7 function. Consequently, Zn2+ ejecting agents that disrupt the zinc knuckle domains were proposed to result noninfectious viruses. Herein, we present the molecular dynamics studies to understand the dynamical properties of the NCp7 in the aqueous phase. These theoretical approaches provide the insight of the critical role of the zinc knuckle in relation to the control of NCp7 functions at a molecular level.

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