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  • 09월 04일 13시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Silver-Mediated Direct Amination of Benzoxazoles: Tuning the Amino Group Source from Formamide to Parent Amines

등록일
2009년 8월 14일 14시 25분 47초
접수번호
1052
발표코드
37P249포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 <발표Ⅲ>
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
조승환, 김지영, 장석복
KAIST 화학과, Korea

The construction of C−N bonds of (hetero)aromatic compounds are manifestly important transformation in synthetic chemistry since it can offer nitrogen-containing molecules of great interest in biological, pharmaceutical, and materials sciences. During the past decades, remarkable progresses have been made in the metal-facilitated C−N bond forming-reactions such as hydroamination or oxidative amidation of double or triple bonds as well as the Buchwald-Hartwig type cross couplings. Despite these significant advances, direct installation of amino groups or their surrogates on aryl- or alkyl C-H bonds is still highly challenging. In this poster, we will describe unprecedented Ag-mediated C−N bond formation of benzoxazoles by the decarbonylative coupling with formamides. On the basis of the mechanistic consideration, we also developed a direct amination protocol with parent amines under highly mild conditions. During the study of catalytic system for this reaction, we found that catalytic amount of other transition metal (eg. Co, Mn) with peroxide instead of using stoichiometric silver were employed for this amination reaction. Further insight into the scope and mechanism of catalytic system are now under investigation.


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