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  • 09월 04일 13시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Number and position dependent change in the binding mode of cationic porphyrins on the poly[d(A-T)2] template

등록일
2009년 8월 14일 14시 58분 29초
접수번호
1132
발표코드
34P210포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅰ>
발표형식
포스터
발표분야
물리화학
저자 및
공동저자
이상화, 권용준, 이동진1, 이재철2, 김석규
영남대학교 화학과, Korea
1경일대학교 공업화학과, Korea
2삼척대학교 식품영양학과, Korea

Binding modes of cationic porphyrins to DNA are affected by various factors including the salt concentration and temperature of medium, position and number of positive charges on the periphery group, coordination number of the central metal, and the DNA sequence. The binding modes change also with time. Change in binding mode of various cationic porphyrins (Figure) on poly[d(A-T)2] was investigated by absorption, circular and linear dichroism (CD and LD), and fluorescence techniques in this study. For all porphyrins, rapid decrease in absorbance in the Soret absorption band followed by a very slow decrease was observed: the latter change likely due to the aggregation of the DNA-porphyrin complex. The extent of change was the largest for TMPyP. In the CD spectrum, magnitude of the bisignate CD spectrum decreases in TMPyP case while the negative band in the short wavelength region becomes positive in both trans- and cis-BMPyP case as the time pass by suggesting the appearance of monomerically bound porphryin in trans- and cis-BMPyP case.


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