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Enantiomer separation of N-hydrazide derivatives of chiral acid drugs on crown ether derived chiral stationary phase

등록일
2009년 8월 14일 15시 59분 20초
접수번호
1280
발표코드
35P123포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 <발표Ⅳ>
발표형식
포스터
발표분야
분석화학
저자 및
공동저자
김경옥, 황호, 이원재
조선대학교 약학대학, Korea
The chromatographic enantiomer separation of N-hydrazide derivatives of NSAIDs (non-steroidal anti-inflammatory drugs), one of important chiral acid types was performed on crown ether type chiral stationary phases (CSPs) derived from (+)- and (-)-(18-crown-6)-2,3,11,12-tetracarboxylic acid (18-C-6-TA). After preparation of the corresponding N-hydrazide derivatives to introduce amino moiety to the chiral acids of NSAIDs, the indirect enantiomer separation was performed using the mobile phase of 80% methanol containing 10mM sulfuric acid with UV detection at 210 nm and, in general, the enantiomers of N-hydrazide derivatives of the examined analytes except ketoprofen were well resolved. It was shown that the elution orders on CSP 1 derived from (+)-18-C-6-TA were reversed on CSP 2 derived from (-)-18-C-6-TA. Using the analytical method applied in this study, liquid chromatographic enantiomer resolution of other chiral acids as their N-hydrazide derivatives is expected to be used on crown ether derived CSP.

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