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Activation of SIRT1 by resveratrol inhibits matrix metalloproteinase-9 in HT1080 cells

등록일
2009년 8월 14일 16시 24분 03초
접수번호
1302
발표코드
36P218포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅱ>
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
이수진, 김문무1
동의대학교 화학과, Korea
1동의대학교 자연대학/화학과, Korea
The aim of this study is to investigate the inhibitory effect of SIRT1 activator, resveratrol, on expression of matrix metalloproteinases (MMPs) involved in metastasis and chronic inflammation. Resveratrol has been reported to be an antioxidant contained in red wine and help to prevent development of cardiovascular diseases such as arteriosclerosis. In gelatin zymography assay, resveratrol exhibited the inhibitory effect on expression of MMP-9 in HT1080 cells with or without stimulation of phorbol myristate acetate. In addition, it was observed that the level of MMP-9 expression was reduced in the presence of resveratrol above 16 uM. Resveratrol inhibited the activation of ERK, a MAP Kinase downregulated by both NF-kB and AP-1 transcription factors in western blot analysis. However p38 was not influenced by resveratrol treatment. The expression level of histone deacetylase, SIRT1 was not changed by resveratrol. These results suggest that the activation of SIRT1 by resveratrol inhibits expression of MMP-9 in HT1080 cells.

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