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Synthesis,Structure and Spectroscopic Properties of Methyl 2-(1,1’-pentyl)-2-devinyl pyropheophorbide-a Derived from methyl Pyropheophorbide a

등록일
2009년 8월 21일 15시 26분 09초
접수번호
1530
발표코드
38P151포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 <발표Ⅳ>
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
Cui Bing Cun, Li Jia Zhu1, 차민욱1, 박호성2, 윤일2, 이우경2, 심영기2
인제대학교 나노공학과, Korea
1인제대학교 나노시스템공학과, Korea
2인제대학교 나노공학부, Korea
Methyl pyropheophorbide a was used as a starting material, the aldehyde chlorin was obtained by the protection of ring-E and oxidation of vinyl group at 3-position, Grignard reaction with pentyl magnesium bromide converted the formyl group into the acyl group. The hydroxyl group of sec-alcohol chlorin was oxidized by mixed oxidizing agent consisting of tetrapropylammonium perruthenate and N-methylmorpholine N-oxide to generate 3-acyl pyropheophorbide-a derivative. The Grignard reaction of which with pentyl magnesium bromide was carried out to yield tertiary alcohol chlorin as nucleophilic adduct. The following dehydration of tertiary alcohol chlorin was performed in the dry benzene at reflux and the pentenyl group at 3 position was hydrogenated by using Pd/C as a catalyst to yield Methyl 2-(1,1’-pentyl)-2-devinyl pyropheophorbide-a. The structures of all new compounds were characterized by UV-Vis and 1H-NMR spectra.

Keywords: Methyl pyropheophorbide-a ; Methyl 2-(1,1’-pentyl)-2-devinyl pyropheophorbide-a ; Photodynamic therapy

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