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Polymer-Protected DNA-Au Nanoparticle Conjugates with High Solubility and Stability

등록일
2009년 8월 21일 15시 50분 05초
접수번호
1542
발표코드
39P327포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 <발표Ⅳ>
발표형식
포스터
발표분야
재료화학
저자 및
공동저자
임동권, 남좌민
서울대학교 화학부, Korea
Here, we developed a polymer-based method to prepare DNA-modified AuNP conjugates with a high solubility and stability in various environments. We found out that PVP polymers form layers around DNA-AuNPs to greatly enhance particle stability at very low pH, high temperature and high salt concentration. Moreover, these PVP-DNA-AuNPs exhibited a long-term stability even under 60 ˚C and pH 2.5. In addition, the PVP layer on DNA-AuNP enabled the DNA-AuNP conjugates to be soluble in hydrophobic organic solvent. Finally, the PVP protection layer could be readily removed with a simple chloroform washing procedure for the effective use of AuNP surface-modified DNA as biosensing applications. We believed that the PVP-coated DNA-AuNP conjugates could expand the applications of DNA-AuNPs, including artifical coding applications in various conditions and environments, and our strategy opens revenues of improving probe stability using a polyrmer-based probe protection strategy.

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