KCS

For a long time Ozonides were only of academic interest. In resent years, however, they attract considerable interest as potential novel antimalarials. The Synthesis of ozonides could be rationalized by cycloaddition of carbonyl oxide and the carbonyl compounds which are derived from the primary ozonide of olefins. Then they get corresponding ozonide by recombination of cycloaddition. All of the ozonides have been isolated by column chromatography on silica gel. The structures of all isolated Ozonides were established by 1H-NMR and 13C-NMR spectroscopy, and their reduction with triphenylphosphin to give the expected carbonyl compounds.