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Simultaneous analysis of pharmaceuticals in environmental sample by liquid chromatography coupled with electrospray ionization tandem mass spectrometry

2009년 8월 21일 16시 13분 35초
35P144포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 <발표Ⅳ>
저자 및
박미선, 조현우, 명승운
경기대학교 화학과, Korea
Pharmaceutical substances are used extensively in human and veterinary medicine. The drugs that human and animal take are not entirely absorbed by bodies, and are excreted and passed into water and treated water. Therefore, it required rapidly and certainly analysis method for pharmaceuticals which are existed in environment. Increased attention is currently being paid to pharmaceutical substances as a class of environmental contaminants. In this study, we established the simultaneous analysis method of pharmaceuticals substances (Erythromycin, Tylosin, Virginiamycin and Cimetidine) from aqueous environmental sample. Effective sample clean-up and extraction by solid-phase extraction (SPE) prior to LC-MS/MS analysis were performed. Liquid chromatography/tandem mass spectrometry (LC-MS/MS) with electrospray ionization (ESI) was used to the qualification and quantitation of five pharmaceuticals. The developed method gave good precision, accuracy, LOD and LOQ. A linear correlation observed in the calibration curves for water over the range of 0.01∼3.0 ng/mL showed above r2=0.99. Absolute recovery was the range of 56.8%∼106.0%. Limit of detection (LOD) and limit of quantitation (LOQ) were the range of 6.6∼60.0 pg/mL and 22.0∼200.0 pg/mL respectively. The established method can be used to determine low pg/mL levels of pharmaceutical substances from the water and treated water.