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Beyond Genes

등록일
2009년 8월 24일 14시 49분 51초
접수번호
1577
발표코드
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발표시간
수 17시 : 00분
발표형식
특별강연
발표분야
특별강연
저자 및
공동저자
Roger D. Kornberg
Stanford University, Korea
Constant transcription of the genetic information in the DNA is a central process for all living beings. The DNA-molecule itself lies protected within the cell nuclei. The genetic information therefore needs to be copied and transformed into what is called messenger-RNA, which carries the information out into the protein-producing parts of the cells. It is the proteins that in their turn actually construct the organism and its function. If the transcription process is interrupted the organism will soon die, since all protein production in the cells ceases. This is what happens in cases of poisoning by certain types of toadstools, like the death cap. The toxin in the death cap blocks the function of a specific enzyme, RNA-polymerase, which plays a central role in the transcription process. Within a few days the toxin spreads from the bowels to the liver and kidneys, hence slowly destroying all these organs. Many illnesses – like cancer, heart disease, and different kinds of inflammation – are also linked to disturbances in the transcription process.

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