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제105회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Single Molecule SERS probed by Nano Raman Spectroscopy

2010년 2월 11일 18시 50분 22초
금27H1구 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 14시 : 00분
물리화학 - 물리화학에서의 최근 연구
저자 및
한국화학연구원 나노바이오융합연구센터 분자고등검지그룹(LAMP), Korea
Since single molecule Surface-Enhanced Raman Scattering(smSERS) was independently reported by S. Nie group and K. Kneipp group in 1997 [1~4], tremendous amount of interest has been shown to this field because Raman spectroscopy can provide molecular fingerprint together with multiplexing capability in bioassay. However, formation of these smSERS-active nanostructures, mostly dimer or colloidal aggregation of Ag or Au nanoparticles adsorbed with Raman active molecules (e.g., Rhodamine 6G), is a random process driven by salt-induced non-specific aggregation. This fact has been a main hurdle for smSERS toward advanced applications. Based on the idea that controlling this nano gap between two noble metal nanoparticles is the key to realize reliable smSERS, we have designed a gold-silver nano dumbbell (GSND). Two gold nano particles with different sizes were linked to each other by double helix DNA (30mer), with a single Raman dye molecule at the center position, to fix the two at a known gap distance (~10 nm). Then we narrowed the gap down to < 1 nm by standard silver staining method to endow the GSND with single molecule sensitivity. We have successfully detected smSERS signals, as well as typical single molecular blinking and polarization behaviors, from each GSNDs by Nano Raman spectroscopy at the single particle level [5]. References [1] S. Nie and S. R. Emory, Science. 275, 1102 (1997) [2] K. Kneipp, Y. Wang, H. Kneipp, L. T. Perelman, I. Itzkan, R. R. Dasari, and M. S. Feld, Phys. Rev. Lett. 78, 1667 (1997) [3] A. M. Michaels, M. Nirmal, and L. E. Brus, J. Am. Chem. Soc. 121, 9932 (1999) [4] Y. D. Suh, G. K. Schenter, L. Zhu, and H. P. Lu, Ultramicroscopy 97, 89 (2003) [5] D. Lim, K.-S. Jeon, H.M. Kim, J. –M. Nam, and Y.D. Suh, Nature Materials 9, 60 (2010)