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학술발표회초록보기

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제105회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Darkfield based label-free assays of Amyloid-beta growth on SLB

등록일
2010년 2월 24일 19시 32분 35초
접수번호
1351
발표코드
39P316포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 <발표Ⅳ>
발표형식
포스터
발표분야
재료화학
저자 및
공동저자
박안나
서울대학교 화학부, Korea
A century of research has passed since the discovery and definition of Alzheimer disease(AD), the primary common dementing worldwide. However, AD has been considered as a fatal disease due to the absence of diagnosis techniques on early stages as well as effective cure currently. To develope the treatments and advanced diagnosis methods, it is essential to understand the etiopathogenesis of amyloid beta-induced neurotoxicity of AD, especially in terms of the deposition of amyloid beta protein in fibrillar form on neuronal cells. Much effort has been directed towards establishing quatitative in vitro assays of this biological process, however, traditional experimental methods using Congo-red and Thioflavin T exhibit the problems. In this research, I suggest label-free technologies focussed on acheiving the observation of Amyloid beta growth without the requirment for fluorophore marker molecules. ;in particular gold nanoparticles and darkfield microscopy provide advantageous alternatives to traditional methods. Moreover, introducing model membranes for the study of Amyloid beta confers analygous environments with in vivo as lipid membranes have a siginificant role in the amylid beta aggregation process.

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