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학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

현재 가능한 작업은 아래와 같습니다.
  • 03월 10일 13시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제105회 대한화학회 학술발표회, 총회 및 기기전시회 안내 [입재물리화학상수상기념강연] A Story of Proline for Two Decades

등록일
2010년 3월 27일 12시 01분 12초
접수번호
1475
발표코드
목10A1분념 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 14시 : 00분
발표형식
분과기념
발표분야
물리화학 - 분자구조 및 화학반응동력학:물리화학자의 관점
저자 및
공동저자
강영기
충북대학교 화학과, Korea
The proline (Pro) residue is unique because the side chain is bonded to the amide nitrogen and the N-C rotation is restrained at about -60°. The prolyl five-membered ring may adopt two distinct puckered conformations, both frequently encountered in X-ray structures of peptides and proteins. The peptide bond is known to dominantly prefer the trans conformation in proteins. Analyses of X-ray protein structures show that the cis populations are ~6% for the prolyl peptide bond and ~0.04% for the nonprolyl peptide bond. It has been reported that the cis-trans isomerization of the X-Pro bond is often involved in the rate-determining steps for folding and refolding of various proteins. In addition, the prolyl cis-trans isomerization was reported to serve as molecular switches or timers in several biological systems. In this talk, I will focus on why proline has been interested and what known for proline by previous quantum-chemical studies. In addition, the ongoing works explored by recently developed density functionals with dispersion corrections and their applicability to the conformational study of bioactive peptides will be addressed.

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