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  • 03월 10일 13시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제105회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Large-scale Synthesis of Uniform-sized Nanocrystals and their Designed Assembly for Multifunctional Biomedical Applications

2010년 3월 27일 13시 19분 29초
목14C1심 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 14시 : 00분
생명화학 - 바이오 활용 나노기술과 의약기술
저자 및
서울대학교 화학생물공학부, Korea
We developed a new generalized synthetic procedure, called as “heat-up process,” to produce uniform-sized nanocrystals of many transition metals and oxides without a size selection process (see review article: Angew. Chem. Int. Ed. 2007, 46, 4630). Very recently we were able to synthesize uniform oxide nanocrystals as much as 1 kilogram-scale from the thermolysis of metal-oleate complexes. Clever combination of different nanoscale materials will lead to the development of multifunctional nano-biomedical platforms for simultaneous targeted delivery, fast diagnosis, and efficient therapy. In this presentation, I would like to present some of our group’s recent results on the designed fabrication of multifunctional nanostructured materials based on uniform-sized nanoparticles and their bio-medical applications. We developed a new T1 MRI contrast agent using biocompatible manganese oxide (MnO) nanoparticles, exhibiting detailed anatomic structures of mouse brain. We reported on the fabrication of monodisperse nanoparticles embedded in uniform pore-sized mesoporous silica spheres and PLGA polymers for simultaneous MRI, fluorescence imaging, and drug delivery. We used ferromagnetic iron oxide nanocrystals for T2 MRI contrast agent for tracking transplanted pancreatic islet cells. We synthesized hollow magnetite nanocapsules and used them for both the MRI contrast agent and magnetic guided drug delivery vehicle.