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학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

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  • 03월 10일 13시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제105회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Theragnostic Chiotsan-based Nanoparicles for Cancer Imaging and Therapy

등록일
2010년 3월 27일 13시 23분 40초
접수번호
1480
발표코드
목14C3심 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 15시 : 00분
발표형식
심포지엄
발표분야
생명화학 - 바이오 활용 나노기술과 의약기술
저자 및
공동저자
김광명
KIST, Korea
Herein, we report that a new nano-sized carrier of tumor-homing chitosan-based nanoparticles (CNP) that can be used not only as nano-sized carriers of an anticancer drug (Paclitaxel; Dodetaxel, doxorubisin, photosensitizer, so on), but also nano-sized imaging probes for in real-time tracking CNPs in live animals. With the help of optical imaging technology, the in real-time and non-invasive destination of CNPs in live animal was monitored to elucidate mechanisms responsible for the targeting efficacy, in vivo biodistribution and optimal treatement conditions of CNPs in tumor-bearing mice. The biocompatible and biodegradable CNPs, that contains encapsulated anticancer drugs and near-infrared (NIR) fluorescence (Cy5.5) accumulated selectively and efficiently in tumor and they enhanced the efficacy of the drug against tumor and also reduced its toxicity. This new approach for nano-sized carriers with anticancer drugs and imaging probes simultaneously may provide a new strategy for rational design of cancer diagnostics and therapy (cancer theragnosis), allowing early detection and then followed by effective targeted therapeutics.

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