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학술발표회초록보기

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제106회 대한화학회 학술발표회, 총회 및 기기전시회 안내 A New Platform for enhanced siRNA Delivery based on Gold Nanoparticles

등록일
2010년 8월 30일 23시 06분 37초
접수번호
1525
발표코드
Ⅳ-MAT.P-148 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 <발표Ⅳ>
발표형식
포스터
발표분야
재료화학
저자 및
공동저자
유수윤, 장홍제, 민달희
KAIST 화학과, Korea
Gold nanoparticles are inorganic nanoparticles which possess unique characteristic electrical, optical, and thermal properties. Gold nanoparticles have great potentials for cellular delivery in therapeutic applications as well as biosensor, and in vivo imaging. Gene therapy based on oligonucleotides (DNAzyme, siRNA, and DNA etc.) has faced the challenge in achieving the successful delivery system which can be one of powerful strategy to treat various diseases. Gold nanoparticles are tunable materials showing the shape- and size- dependent properties and these structurally fabricated nanostructures can further improve their unique properties. In this report, a class of gold nanoparticles with various diameters were synthesized and used as novel carriers for mammalian cell transfection and the cytotoxicity of these particles was tested. We believe that the geometry and biocompatibility of the gold nanoparticles make this nanomaterial suitable for DNA/RNA transfection carrier.

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