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제106회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Total Synthesis and Stereochemistry of Mycolactone F

등록일
2010년 8월 31일 10시 42분 04초
접수번호
1537
발표코드
Ⅳ-ORGN.P-312 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 <발표Ⅳ>
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
김한제, Yoshito Kishi1
공주교육대학교 과학교육과, Korea
1Department of Chemistry and Chemical Biology, Harvard University, U.S.A., United States
Buruli ulcer is a severe necrotizing skin disease caused by Mycobacterium ulcerans. In 1999, Small and coworkers isolated the toxic metabolites, named mycolactones A and B, from M. ulcerans. Evidence from animal studies suggested that mycolactones A and B are directly responsible for the observed pathology. Recently, a mycolactone congener, called mycolactone F, was isolated from the fish pathogen M. marinum, and its gross structure was proposed. Intriguingly, mycolactone F was reported to exhibit a significantly lower toxicity. The mycolactones have attracted considerable attention from the synthetic community not only for their highly potent biological activity but also for being the first examples of polyketide macrolides to be isolated from a human pathogen. In this poster, we describe the total synthesis and the stereochemistry assignment of mycolactone F.

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