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  • 09월 09일 18시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제106회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Design, Synthesis, and Applications of Bioinspired Nanoscale Adhesive Agents

2010년 9월 2일 11시 34분 21초
ORGN1-2 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 14시 : 00분
유기화학 - 분자인식화학 국제심포지엄
저자 및
Steven C. Zimmerman
University of Illinois, USA, United States
The high fidelity of DNA replication is partly due to base-pairing specificity. Inspired by DNA we have developed a series of artificial base-pairs that form hydrogen-bonded complexes that exhibit significantly higher stability and higher fidelity relative to their natural counterparts. Particularly useful is a urea of guanosine (UG unit) which pairs with 2,7-diamidonaphthyridine (DAN unit). These units can be readily incorporated into small molecules and macromolecules, and attached to nanoparticles and surfaces, in some cases using "click chemistry." This talk will describe these nanoscale adhesion promoters and the broad range of supramolecular structures that can be produced. The physical organic approach to optimizing their performance will be one theme. Applications possible with these very high affinity recognition units will be highlighted. The agents have been particularly useful in enhancing the energetics at normally unfavorable interfaces at the molecular and materials level. Additionally, stimuli responsive recognition units will be introduced as a way to turn the recognition on and off. The ability to orthogonally address recognition events at the molecular level provides a degree of control necessary to replicate the biocomplexity of naturally occurring systems.