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  • 03월 07일 19시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제107회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Calix[4]pyrrole-Based Fluorescence Indicator Displacement Assay (FIDA) Senosrs for Anions and Their Selectivity Tuning

등록일
2011년 2월 9일 10시 32분 19초
접수번호
0100
발표코드
Ⅱ-ORGN.P-218 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅱ>
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
이창희, Punidha Sokkalingam1
강원대학교 화학과, Korea
1kangwon national university, India
A simple and convenient method to quantitatively determine the fluoride anion concentration in organic media has been reported. We designed and synthesized four cis-5,15-(p-X (X= F (1), Br (2), I (3) and CN (4))phenyl)-(5,10,10,15,20,20-hexamethyl)calix[4]pyrrole receptors that bind strongly with fluorescent indicator. The receptor-bound indicator can be replaced when competitive analytes having greater affinity with receptor have been introduced. We found that the highly fluorescent coumarin derivatives strongly bind with synthesized receptors (Ka = 4.69 x 106 (1); 1.15 x 106 (2); 7.11 x 105 (3) and 1.16 x 106 (4)) with complete loss of fluorescence. When these non-fluorescent, host-chromenolate complex were exposed to the mixture of anions, the bound chromenolate anion was displaced more selectively by fluoride anion ( Ka = 5.96 x 106) with full restoration of fluorescence. While fluoro-substituted receptor showed a greater affinity towards only fluoride anions, the iodo-substituted one exhibited relatively high selectivity for both acetate and fluoride anions. The increase in the fluorescence intensity was found to be closely related with the concentration of added anions. Thus the present work can provide structural foundation for selectively sensing various anions by introducing suitable substituent in the receptor.

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