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제107회 대한화학회 학술발표회, 총회 및 기기전시회 안내 A direct route to triazole organotrifluoroborates via 1,3-dipolar cycloaddition and their cross-coupling reactions

등록일
2011년 2월 17일 13시 21분 04초
접수번호
0615
발표코드
Ⅱ-ORGN.P-197 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅱ>
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
볼라, 송중호1, 김태정2, 박순혜2, 이혜진3, 함정엽4
과학기술연합대학원대학교 Dept.of Med.Chem., Korea
1강릉대학교 화학신소재학과, Korea
2한국과학기술연구원 천연물소재센터, Korea
3강릉대학교 화학신소재, Korea
4한국과학기술연구원 천연물소재연구센터, Korea
Over the past decades organotrifluoroborates have been used in many contexts as valuable synthetic pre-cursors in Suzuki-Miyaura reaction due to their stability, inexpensive routes for the preparation. Also, organotrifluoroborates can be functionalized to build molecular complexity, while leaving the B-C bond intact. On the other hand, “Click Chemistry” has emerged as a fast and efficient approach to synthesis of novel compounds with desired function making use of selected ‘near perfect’ reactions. The 1,2,3-triazole ring is regarded as an important pharmaco-phore in drug discovery research and shown interesting biological properties. During the study of triazole preparation, we found that a scaffold bearing a -BF3K at C-4 position in 1,2,3-triazole ring which would represent an attractive functional group target for various synthetic applications. Herein, we are going to report the preparation of 1,4-disubstituted triazole organotrifluoroborates with different functional group tolerance and their subsequent cross-coupling reactions.

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