The design and implementation of tandem reactions is a challenging facet and become increasingly important in organic chemistry because of their undeniable ability to create complex molecules in a single reaction without the need to isolate intermediate. Recently, we challenged tandem use of the Blaise reaction intermediate, a zinc bromide complex of β-enaminoester, and accomplished the chemoselective nucleophilic addition to anhydrides, terminal alkynes, and propiolates. In present work, we investigated the reactivity of Blaise reaction intermediate towards epoxide ring opening for the synthesis of γ-butyrolactones.
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