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제107회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis and evaluation of [1,2,4]triazolo[3,4-α] isoquinolines as potential antibacterial agents of resistant strains of Nosocomial pathogen Acinetobacter baumannii

등록일
2011년 2월 18일 12시 02분 37초
접수번호
0700
발표코드
Ⅱ-ORGN.P-320 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅱ>
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
F.Nawaz Khan, 진종성1, 정의덕1, P.Manivel, M.R.Rajeswari2, 이미성3, 문해경4
Organic Chemistry Division, School of Advance Sciences, VIT University, India, India
1한국기초과학지원연구원 하이테크부품소재연구지원센터, Korea
2Department of Biochemistry, All India Institute of Medical Sciences, India, India
3부산대학교 화학과, Korea
4한국기초과학지원연구원 하이테크소재연구부, Korea
Today, the resistance development to antimicrobials is a major problem in confronting organized health care, the widespread use of antibiotics plays a major role in increase of antimicrobial resistance. Acinetobacter baumannii organism, an opportunistic, gram negative, cocco-bacillus bacterium account for a large percentage of nosocomial infections like septicemia, bacterimia, pneumonia, wound sepsis, endocarditis, meningitis, and urinary tract infections. The most challenging part of these infections is the extensive antimicrobial drug resistance and emergence of strains that are resistant to all commercially available antibiotics. These strains are invariably multidrug resistant and show resistance against most of the commonly used antibiotics like penicillins, aminoglycosides, cephalosporins, and even fluoroquinolones and the lack of new antimicrobial agents in development. Various 1, 2, 4-triazoles have been extensively explored for their applications in the field of biological and pharmacological activities, including antifungal, bactericidal, anxiolytic, anticonvulsant, or herbicidal and antidepressant activitie. Therefore, it was envisaged that chemical entities with 1, 2, 4-triazole might result in compounds with interesting biological activity. .In view of this we report herein, a convenient, practical and efficient method for the synthesis of [1, 2, 4]triazolo[3,4-α]isoquinolines and the antibacterial activity of the triazoles against resistant strains of Acinetobacter baumannii was explored.

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