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  • 03월 07일 19시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제107회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Novel synthesis of 2-iminooxazoline from α-hydroxy-ketones by using Lewis acid catalyst

등록일
2011년 2월 21일 09시 59분 19초
접수번호
0735
발표코드
Ⅱ-ORGN.P-327 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 <발표Ⅱ>
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
한민수, 남기달1, 정낙철, 한호규1
고려대학교 화학과, Korea
1한국과학기술연구원 생체과학연구부, Korea

Synthetic methods available for the construction of heterocyclic molecules can be used to affect a number of valuable synthetic transformations. We recently reported a synthesis of 2-imino-1,3-thiazolines which showed antifungal and T-type channel inhibitory activities. 2-Imino-1,3-thiazolines are isoform of 2-amino-1,3-thiazole, which known to be privileged structure in the medicinal chemistry for development of new pharmaceuticals. As an extention of our studies of lead optimization of this series, we now report here a novel synthesis of 2-imino-1,3-oxazolines from the reaction of α-hydroxy-ketone and diimide in the presence of Lewis acid catalyst. 2-Imino-1,3-oxazolines are oxygen analogue of 2-imino-1,3-thiazolines and expected to show biological activity. While 2-imino-1,3-thiazolines were synthesized by the reaction of α-halo-ketone and thiourea in quantitative, the oxygen analogue, 2-imino-1,3-oxazolines could not prepared by the reaction of α-halo-ketone and urea. The synthetic methodology report here is convenient for preparation of 2-imino-1,3-oxazoline derivatives. We also discuss the regiochemistry of the products.


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