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제107회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis of DNA-Organic Molecule-DNA Triblock Oligomers And their Amplification Using the PCR Method

2011년 2월 24일 15시 26분 33초
Ⅳ-ORGN.P-317 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 <발표Ⅳ>
저자 및
정영환, Jungkyu K. Lee1, Zhenan Bao1
한국폴리텍바이오대학 바이오생명정보과, Korea
1Stanford University, U.S.A., United States
Molecular electronics, which involves molecular building blocks as active electronic elements, has been the subject of intense research for many years because of the fundamental interests in molecular charge transport and potential applications. Molecular electronics requires a method for making reliable electrical contacts to single-molecules. DNA has been used as a template for metallic nanostructures, such as Ag, Au, Pd, and Cu nanowires. We envision using a DNA-organic molecule-DNA (DOD) triblock architecture, where the DNAs are subsequently “metallized”to enable contacts to a single molecule. Long double strand DNAs (dsDNAs) (>a few-hundred nanometers) are needed to tether individual molecules to lithographically patterned microscopic electrodes. As a key first step, we demonstrate the synthesis of such triblock adducts and their subsequent elongation to construct molecular electronic suitable DOD architectures using polymerase chain reaction (PCR). We have successfully developed a simple and versatile approach using PCR to synthesize triblock architectures comprising “long dsDNA-organic molecule-long dsDNA.” The amide-coupling reactions allowed us to incorporate molecules with 3′-ODN end substitutions and can be easily extended to introduce other organic molecules to build various ODN nanostructures, for example three-armed ODN nanostructures. Moreover, the PCR method is a powerful tool to rapidly build micrometer-scaled DNA structures from the ODN precursors. By incorporating organic molecules with interesting electronic properties, this strategy could constitute a versatile biomolecule-based platform for single molecule electronics.