abs

학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

현재 가능한 작업은 아래와 같습니다.
  • 03월 07일 19시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제107회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Navigation in Biologically Relevant Chemical Space

등록일
2011년 3월 18일 15시 49분 57초
접수번호
1770
발표코드
ORGN1-1 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 13시 : 30분
발표형식
분과기념
발표분야
유기화학 - International Symposium on Organic Chemistry (1) : Recent Developments on the Catalysis and Natural Product Synthesis
저자 및
공동저자
김상희
서울대학교 약학대학/약학과, Korea
Chemical space is infinite and limited only by the chemist’s imagination. Within chemical space, biologically relevant chemical space is amazingly small compared to the possible chemical space. Although it is small, some estimates of this number are in excess of 1060. This number is huge far more than we can comprehend. We chemist have a rich array of skills and techniques with which we can create or discover small organic compounds that can be used for biological systems. Despite such expert knowledge, the registered number of small organic compounds is only around 2x107. This number is insufficient to examine the entire biological space. Indeed, it is practically impossible and irrelevant to build the complete biologically relevant chemical space. Thus, scientists have been guided by Nature in navigating biologically relevant chemical space to identify regions containing relevant bioactive compounds. The possibility that natural products and endogenous compounds will be biologically relevant is very high, since they are evolutionarily selected, biologically pre-explored, and validated by Nature. Understanding the link between natural/endogenous products and biological space prompted us to explore the biologically relevant chemical space through chemical modification to understand the fundamental processes of life and to develop new strategies for identifying potential drug candidates. In this presentation, I would like to share our current efforts on this filed. This involves the synthesis of natural/endogenous products, design and evaluation of their mimetics, and preparation of natural product-like compounds library.

상단으로