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  • 03월 07일 19시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제107회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Navigation in Biologically Relevant Chemical Space

2011년 3월 18일 15시 49분 57초
ORGN1-1 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 13시 : 30분
유기화학 - International Symposium on Organic Chemistry (1) : Recent Developments on the Catalysis and Natural Product Synthesis
저자 및
서울대학교 약학대학/약학과, Korea
Chemical space is infinite and limited only by the chemist’s imagination. Within chemical space, biologically relevant chemical space is amazingly small compared to the possible chemical space. Although it is small, some estimates of this number are in excess of 1060. This number is huge far more than we can comprehend. We chemist have a rich array of skills and techniques with which we can create or discover small organic compounds that can be used for biological systems. Despite such expert knowledge, the registered number of small organic compounds is only around 2x107. This number is insufficient to examine the entire biological space. Indeed, it is practically impossible and irrelevant to build the complete biologically relevant chemical space. Thus, scientists have been guided by Nature in navigating biologically relevant chemical space to identify regions containing relevant bioactive compounds. The possibility that natural products and endogenous compounds will be biologically relevant is very high, since they are evolutionarily selected, biologically pre-explored, and validated by Nature. Understanding the link between natural/endogenous products and biological space prompted us to explore the biologically relevant chemical space through chemical modification to understand the fundamental processes of life and to develop new strategies for identifying potential drug candidates. In this presentation, I would like to share our current efforts on this filed. This involves the synthesis of natural/endogenous products, design and evaluation of their mimetics, and preparation of natural product-like compounds library.