abs

학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

현재 가능한 작업은 아래와 같습니다.
  • 08월 24일 19시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Polymorphisms of tumor necrosis factor (TNF) α in Korean patients with Behcet's disease

등록일
2005년 8월 11일 14시 31분 23초
접수번호
0892
발표코드
24P138포 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 <발표Ⅱ>
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
박상범, 남윤형, 박대용, 이재식, 강원, 안영창, 이상현, 장원철, 장현규1
단국대학교 첨단과학대학 화학전공,
1단국대학교 의과대학 류마티스내과,
Tumor necrosis factor α (TNFα) is potent inflammatory cytokine. In human, the TNFα gene is located within the highly polymorphic major histocompatibility complex (MHC) region on chromosome 6p21.3. TNF gene cluster contains many polymorphisms including microsatellites and single nucleotide polymorphisms (SNPs). This study tries to determine whether -1031 T/C, -863 C/A and -857 C/A polymorphisms are associated with susceptibility to Behcet's disease in Koreans. The three polymorphisms were typed by direct sequencing. In the position -1031 T/C in TNFα gene, TT type was detected in 55.34% (57/103), TC type 39.81% (41/103) and CC type 4.85% (5/103) of the normal control population compared with TT type was detected in 52.21% (59/113), TC type 41.59% (47/113) and CC type 6.20% (7/113) of all patients with BD. In the position -863 C/A in TNFα gene, CC type was detected in 64.08% (66/103), CA type 33.98% (35/103), and AA type 1.94% (2/103) of the normal control population. CC type was detected in 60.18% (68/113), CA type 34.51%(39/113) and AA type 5.31% (6/113) of all patients with BD. In the position -857 C/T in TNFα gene, CC type was detected in 71.84% (74/103), CA type 28.16% (29/103), and AA type 0% (0/103) of the normal control population. CC type was detected in 65.48% (74/113), CA type 32.74%(37/113) and AA type 1.78% (2/113) of all patients with BD. There were no evidences for genetic association conferred by the TNFα with respect to susceptibility to BD.

상단으로