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제108회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Unprecedented 3D Molecular Architectures by the Controlled Self-Assembly of Foldamers

등록일
2011년 8월 26일 13시 25분 46초
접수번호
1650
발표코드
ORGN-1 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 13시 : 30분
발표형식
분과기념
발표분야
유기화학 - Recent Trends in Organic Chemistry
저자 및
공동저자
이희승
KAIST 화학과, Korea
Molecular self-assembly is the spontaneous assembly of molecules into structured aggregates by which nature builds complex functional systems. While numerous examples have focused on 2D self-assembly to understand the underlying mechanism and mimic this process to create artificial nano- and microstructures, a limited progress has been made toward 3D self-assembly on the molecular level. This lack of progress is partially due to the difficultly of designing and using nondirectional noncovalent interactions, such as van der Waals and hydrophobic interactions, in synthetic, nonbiological molecular systems. Thus, we sought to establish a set of self-assembling components that could be linked to observable 3D shapes by which the governing parameters of self-assembly could be disentangled and tractable. Recently, we discovered that artificial protein fragments (helical β-peptide foldamers) with well-defined hydrophobic surfaces self-assembled to form unprecedented 3D molecular architectures in a controlled manner in aqueous solution. We anticipate that our strategy can be a starting point for the rational design of 3D organic molecular architectures with various functions. Furthermore, the self-assembly behavior of artificial protein fragments will be relevant for the development of synthetic foldamer proteins.

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